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. 2017 May 29;3:17015. doi: 10.1038/cddiscovery.2017.15

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Cellular uptake and nuclear accumulation of cfCh and their prevention by chromatin neutralizing/degrading agents. (a) Representative laser scanning confocal microscopy images showing nuclear uptake of numerous fluorescent particles by NIH3T3 cells released from dead Jurkat cells pre-labeled with BrdU at 6 h. The uptake of cfCh is prevented by concurrent treatment with CNPs, DNase I and R-Cu. Few nuclear fluorescent signals are seen when live Jurkat cells were used. (b) Quantitative analysis of mean fluorescence intensity (MFI) of images given in a. Fifty nuclei were analyzed for quantifying MFI. Data were analyzed by Student’s t-test. ****P=0.0001. J, Jurkat cells.