Fig. 3.

Relationships between P450c17 expression and patient age and serum E₂ levels. (A) Representative images of P450c17 expression. Samples are strongly positive (score 2) for P450c17 in luteinized cells (left upper), and weakly positive (score 1) for P450c17 in theca- or fibroblast-like cells (middle upper) and tumor cells (upper right), as determined by immunohistochemistry (original magnification: ×40). (B) Number of cases positive (score 1 or 2) or negative (score 0) for P450c17 among patients under and over 50 years of age (n=14 and 16, respectively). (C) Number of cases positive or negative for P450c17 among patients with serum E₂ below or above 30 pg/mL (n=10 and 11, respectively).

E₂, 17β-estradiol; H&E, hematoxylin and eosin staining; ns, not significant; P450c17, P450 17α-hydroxylase.

^*p<0.05 (B, C: Fisher's exact test).