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The methylation level of the HPV L1 region in cervical brushings diagnosed with different levels of CIN. The methylation status detected by bisulfate-pyrosequencing in (A) HPV16, (B) HPV18, (C) HPV52, and (D) HPV58 at the indicated CpG sites, with the p-value shown above the graph.
CIN, cervical intraepithelial neoplasia; CpG, C-phosphate-G; HPV, human papillomavirus; L1, late gene 1; Meth., methylation.
