Table 4.

Annual Lung Cancer Detection Rate

	N	No. LC	Duration (yr)	LCDR	95% CI	NND
P-IELCAP cohort*
P-IELCAP	1,696	25	3.47	0.43	0.29–0.63	235
NLST	660	13	3.80	0.52	0.30–0.89	193
NLST/E	883	22	3.47	0.72	0.47–1.09	139
P-IELCAP(E)	394	15	3.07	1.24	0.75–2.06	81
PLuSS cohort*
PLuSS	3,437	62	4.20	0.43	0.34–0.55	233
NLST	2,047	53	5.41	0.48	0.37–0.63	209
NLST/E	2,514	59	5.31	0.44	0.34–0.57	226
PLuSS(E)	1,433	40	5.71	0.49	0.36–0.67	205

Definition of abbreviations: CI = confidence interval; (E) suffix = limitation of annual low-dose chest computed tomography in P-IELCAP and PLuSS to individuals with emphysema; LCDR = lung cancer detection rate; NLST = National Lung Screening Trial; NLST/E = extended NLST subcohort including individuals with emphysema independent of NLST; No. LC = number of lung cancers; NND = number of people needed to be screened in a year to detect one lung cancer; P-IELCAP = Pamplona International Early Lung Cancer Action Program; PLuSS = Pittsburgh Lung Screening Study.

^*Only lung cancers diagnosed at or after the second round of screening (incident cancers) are considered.