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. Author manuscript; available in PMC: 2017 Oct 31.
Published in final edited form as: Mol Psychiatry. 2017 Feb 21;22(11):1594–1603. doi: 10.1038/mp.2017.4

Figure 1. Pregnenolone blocks the cognitive impairment induced by THC.

Figure 1

(A) Dose-response of THC effects in the spontaneous alternation task [1-Way ANOVA, F(3,32)=3.8, p<0.001, n=6-12]. (B) Effect of pregnenolone (6 mg/kg, s.c.) 10 min before or 30 min after THC (3 mg/kg, i.p.) administration on the impairment of spontaneous alternation [before: 2-Way ANOVA, interaction; F(1,58)=14.83, p<0.001; after: 2-Way ANOVA, interaction; F(1,62)=6.871, p<0.05, n=10-20]. (C-D) Effect of pregnenolone (6 mg/kg, s.c.) on the cognitive impairment induced by THC (5 mg/kg, i.p.) in the delayed matching-to-place version of the Morris water maze. (C) Saving ratio for the latency [2-Way ANOVA, interaction, F(1,64)=6.48, p<0.05, n=15-20]. (D) Saving ratio for the path [2-Way ANOVA, interaction, F(1,64)=5.09, p<0.05, n=15-20]. **, p<0.01; ***, p<0.001 for the effect of THC. #, p<0.05; ##, p<0.01 for the effect of pregnenolone in THC injected mice.