Fig. 2.

Oridonin display potent antiproliferative and proapoptotic effects on human breast cancer cells. A: MTT assays showing inhibition of viable cells after a 24-h treatment with different concentrations of oridonin. B and C: cells were treated with oridonin (0, 0.1, 1, 5, and 10 mmol/L) for 24 h, then the percentages of cells undergoing apoptosis were determined by FITC–Annexin V/PI staining and flow cytometry and shown in B, and the percentage of Rh123-negative cells are shown in C. ^*P < 0.05, ^**P < 0.01 compared with the 0 mmol/L group.