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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Trends Genet. 2017 Mar 31;33(5):336–348. doi: 10.1016/j.tig.2017.03.001

Figure 3.

Figure 3

Schematic representation of the effects of U2AF1 mutations on pre-mRNA splicing. (A) Mutations of U2AF1 S34 to F or Y (S34F/Y) sense the identity of the nucleotide at the −3 position (three nucleotides preceding) the intron-exon junction, typically promoting inclusion of sites preceded by −3C (blue) and skipping sites preceded by −3U (red). (B) Mutations of U2AF1 Q157 to P or R (Q157P/R) sense the identity of the nucleotide at the +1 position immediately following the intron-exon junction, typically promoting inclusion of sites followed by +1G (yellow) and skipping sites followed by +1A (green). Exons, black or gray rectangles; spliced junctions are connected by lines.