Table 1.
Evoked Properties.
| Isoform | Nav1.1 | Nav1.6 | ||
|---|---|---|---|---|
|
|
|
|||
| Treatment | DMSO (0.1%) | Deltamethrin (10μM) | DMSO (0.1%) | Deltamethrin (10μM) |
| Peak Current Densitya(pA/pF) | 105.9 ± 33.0 (9) | 154.7 ± 32.4 (19) | 56.1 ± 12.6 (10) | 29.3 ± 4.4 (20) |
| Persistent Current Densityb(pA/pF) | 6.8 ± 3.6 (4) | 68.0 ± 12.2* (19) | −0.4 ± 0.6 (6) | 9.2 ± 2.4* (20) |
| Tail Current Densitya (pA/pF) | 21.4 ± 6.3 (9) | 118.6 ± 18.5* (14) | 5.9 ± 1.5 (10) | 25.1 ± 4.1* (20) |
| Activation (V1/2) | −22.6 ± 2.7 (7) | −27.2 ± 6.7 (12) | −20.7 ± 1.3 (10) | −23.8 ± 1.3 (17) |
| Activation Slope Factor (k) | 2.9 ± 0.42 (7) | 3.9 ± 0.60 (12) | 3.6 ± 0.3 (10) | 5.0 ± 0.3* (17) |
| Persistent Activation (V1/2) | −22.8 ± 1.4 (4) | −34.7 ± 1.1* (16) | N/A | −26.8 ± 1.4 (9) |
| Persistent Activation Slope Factor (k) | 6.5 ± 0.9 (4) | 2.8 ± 0.3* (16) | N/A | 4.7 ± 1.1 (9) |
| Inactivation (V1/2) | −50.4 ± 5.0 (8) | −53.9 ± 4.7 (13) | −56.6 ± 0.8 (12) | −64.5 ± 1.3* (15) |
| Inactivation Slope Factor (k) | 5.9 ± 0.7 (8) | 5.2 ± 0.4 (13) | 5.9 ± 0.2(12) | 5.8 ± 0.3 (15) |
Data are presented as Mean ± SEM.
*
p< 0.05, n in parenthesis.
a
Peaks taken at −10mV.
b
Peaks taken at − 20 mV.