Table 2.
Use-dependent Properties.
| Parameter | HEK-Nav1.1 | HEK-Nav1.6 | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| DMSO (0.1%) | Deltamethrin (10μM) | DMSO (0.1%) | Deltamethrin (10μM) | |||||
| Stimulation Frequency (Hz) |
10 | 5 | 10 | 5 | 10 | 5 | 10 | 5 |
| Peak Current Density (pA/pF) |
63.2 ± 15.0 (10) |
101.6 ± 26.6 (10) |
100.0 ± 17.8 (17) | 121.8 ± 24.2 (17) | 33.3 ± 10.2 (11) |
42.1 ± 12.5 (11) |
21.4 ± 3.6 (19) | 25.5 ± 4.3 (19) |
| % Peak Current Density | 116.4 ± 9.0 (10) |
101.6 ± 2.8 (10) | 98.1 ± 7.1 (17) | 99.9 ± 4.4 (17) | 92.2 ± 4.4 (11) |
96.5 ± 2.4 (11) | 119.0 ± 7.0* (19) | 120.6 ± 8.0* (19) |
| Persistent Current Density (pA/pF) |
−1.6 ± 1.3 (10) | 1.1 ± 2.0 (10) | 54.9 ± 9.1* (17) | 60.5 ± 7.6* (17) | -4.6 ± 2.2 (12) |
−3.5 ± 1.8 (12) |
26.0 ± 7.0* (19) | 11.8 ± 2.5 (19) |
| % Persistent Current Density |
89.6 ± 14.7 (10) |
67.4 ± 27.4 (10) | 75.1 ± 17.8 (12) | 83.6 ± 10.7 (12) | 119.6 ± 14.1 (11) |
136.7 ± 36.0 (11) |
276.8 ± 49.8*
(19) |
253.8 ± 50.8*
(18) |
| Tail Current Density (pA/ pF) |
10.9 ± 2.1 (10) | 17.9 ± 3.4 (10) | 121.1 ± 18.2 (17) | 147.8 ± 18.1* (17) | 13.4 ± 3.9 (12) |
14.3 ± 3.6 (12) |
33.4 ± 4.2* (20) | 45.5 ± 5.7* (20) |
| % Tail Current Density | 103.4 ± 4.0 (10) |
107.7 ± 4.4 (10) | 132.7 ± 10.8 (17) | 127.1 ± 9.8 (17) | 103.9 ± 2.9 (12) |
107.8 ± 4.6 (12) |
137.1 ± 4.8* (20) | 131.0 ± 5.1 (20) |
| Fraction of Available Current |
0.42 ± 0.24 (9) | 0.27 ± 0.06 (9) | 1.23 ± 0.11* (17) | 1.49 ± 0.16 (17) | 0.23 ± 0.29 (11) |
0.10 ± 0.28 (11) |
2.07 ± 0.28*
(19) |
2.12 ± 0.26* (19) |
| Total Charge (Q) | 880.0 ± 292.4 (10) |
1087.4 ± 389.2 (10) |
23247.9 ± 3679.6*
(17) |
28143.5 ± 3745.8*
(17) |
624.1 ± 108.7 (12) |
747.3 ± 218.5 (12) |
5522.2 ± 780.1*
(20) |
6080.3 ± 805.0*
(20) |
Data are presented as Mean ± SEM.
*
p<0.05.