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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Curr Opin Neurobiol. 2017 Feb 23;43:94–101. doi: 10.1016/j.conb.2017.01.006

Figure 2. Role of the MAGUKs in Hebbian and non-Hebbian plasticity.

Figure 2

The MAGUKs are involved in pathways that set synaptic strength during Hebbian and non-Hebbian plasticity. (A) Phosphorylation of the stargazin c-tail by PKC and CaMKII allows robust binding of the c-tail to the PDZ3 domain of PSD-95. This additional binding site increases the number of synaptically localized AMPARs. (B) MAGUKs set default synaptic strength during non-Hebbian homeostasis. 1. PSD size (and MAGUK content) set baseline ‘default’ synaptic strength. 2. Reduction in MAGUK protein fragments and weakens synapses. 3. Non-Hebbian processes work to restore synaptic strength to a pre-existing set point. These processes include distance-dependent scaling, synapse-level homeostasis, and cell-level homeostatic processes.