Fig. 1.

Altered resting state ALFF in MwoA patients.

1A. Brain regions showed increased resting state ALFF in MwoA patients compared to healthy controls; 1B. Brain regions showed reduced resting state ALFF in MwoA patients, compared to healthy controls; 1C. Reduced ALFF value in RVM/TCC is negatively associated with increased headache intensity as indicated by VAS scores in MwoA patients at baseline, controlled for age, gender, disease duration, SAS and SDS. ALFF, amplitude of low frequency fluctuation; L, left side; MwoA, migraine without aura; R, right side; RVM, rostral ventromedial medulla; TCC, trigeminocervical complex; VAS, visual analogue scale; Vst, ventral striatum.