Table 1. Subject Characteristics, Physiologic and Quantitative Measurements.
| Male (n = 67) | Female (n = 97) | P | |
|---|---|---|---|
| Age (years) | 52.5 ± 14.8 | 57.1 ± 13.8 | < 0.05 |
| FVC (% predicted) | 93.2 ± 11.3 | 104.7 ± 13.4 | < 0.001 |
| FEV1 (% predicted) | 98.8 ± 12.3 | 114.6 ± 19.1 | < 0.001 |
| FEV1/FVC (%) | 77.9 ± 7.5 | 80.1 ± 5.6 | 0.032 |
| FEF25–75% (% predicted) | 89.5 ± 23.3 | 98.4 ± 32.4 | 0.055 |
| TLC (% predicted) | 108.8 ± 19.0 | 109.1 ± 21.7 | 0.965 |
| VC (% predicted) | 101.9 ± 28.7 | 108.3 ± 17.6 | 0.468 |
| RV (% predicted) | 110.1 ± 44.9 | 108.8 ± 45.0 | 0.935 |
| DLco (% predicted) | 97.9 ± 18.2 | 90.1 ± 15.9 | 0.181 |
| TLCCT, mL | 5212.5 ± 990.8 | 3725.9 ± 731.0 | < 0.001 |
| FRCCT, mL | 3188.1 ± 838.5 | 2514.5 ± 594.0 | < 0.001 |
| %LAAI-950 | 1.8 ± 3.4 | 1.1 ± 2.7 | 0.165 |
| %LAAE-856 | 17.9 ± 14.9 | 15.9 ± 16.0 | 0.432 |
| HU 15 percentile-inspiration | −908.7 ± 18.8 | −891.7 ± 25.7 | < 0.001 |
| MLA (HU) | |||
| Inspiration | −842.5 ± 23.2 | −823.9 ± 31.1 | < 0.001 |
| Expiration | −751.9 ± 48.3 | −750.6 ± 44.9 | 0.867 |
| Pi10 | |||
| Inspiration | 4.3 ± 0.3 | 4.0 ± 0.2 | < 0.001 |
| Expiration | 4.3 ± 0.3 | 4.1 ± 0.3 | 0.001 |
| Skewness | |||
| Inspiration | 2.5 ± 0.4 | 2.4 ± 0.4 | 0.226 |
| Expiration | 2.4 ± 0.4 | 2.5 ± 0.3 | 0.586 |
| Kurtosis | |||
| Inspiration | 5.1 ± 1.9 | 4.8 ± 2.0 | 0.218 |
| Expiration | 4.9 ± 2.0 | 5.0 ± 1.8 | 0.728 |
DLco = diffusion capacity of lung for carbon monoxide, FEF25–75% = forced expiratory flow between 25–75%, FEV1 = forced expiratory volume in 1 second, FRCCT = functional residual capacity, FVC = forced expiratory vital capacity, HU = Hounsfield unit, MLA = mean lung attenuation, Pi10 = inner perimeter of 10 mm, RV = residual volume, TLC = total lung capacity, VC = vital capacity, %LAAE-856 = percentage of low attenuation area with CT attenuation values less than −856 HU at expiration, %LAAI-950 = percentage of low attenuation area with CT attenuation values less than −950 HU at inspiration