Table 2. Physiologic and Quantitative Measurements in Never-Smokers.
| Male (n = 23) | Female (n = 96) | P | |
|---|---|---|---|
| Age (years) | 54.4 ± 15.4 | 56.9 ± 13.7 | 0.437 |
| FVC (% predicted) | 94.9 ± 11.6 | 104.7 ± 13.5 | 0.002 |
| FEV1 (% predicted) | 101.4 ± 11.7 | 114.6 ± 19.2 | < 0.001 |
| FEV1/FVC (%) | 78.5 ± 5.0 | 80.2 ± 5.6 | 0.179 |
| FEF25–75% (% predicted) | 89.9 ± 20.3 | 98.7 ± 32.4 | 0.219 |
| TLC (% predicted) | 109.3 ± 26.7 | 109.1 ± 21.7 | 0.996 |
| VC (% predicted) | 115.4 ± 41.3 | 108.3 ± 17.6 | 0.586 |
| RV (% predicted) | 93.1 ± 54.1 | 108.8 ± 45.0 | 0.525 |
| DLco (% predicted) | 100.8 ± 24.7 | 90.1 ± 15.0 | 0.238 |
| TLCCT, mL | 5086.3 ± 1196.4 | 3722.7 ± 734.2 | < 0.001 |
| FRCCT, mL | 3146.8 ± 851.4 | 2516.8 ± 597.1 | < 0.001 |
| %LAAI-950 | 2.6 ± 4.6 | 1.1 ± 2.7 | 0.153 |
| %LAAE-856 | 20.0 ± 17.2 | 15.9 ± 16.1 | 0.287 |
| HU 15 percentile-inspiration | −911.4 ± 22.6 | −891.5 ± 25.7 | 0.001 |
| MLA (HU) | |||
| Inspiration | −845.2 ± 28.7 | −823.7 ± 31.1 | 0.003 |
| Expiration | −761.8 ± 46.6 | −750.5 ± 45.2 | 0.291 |
| Pi10 | |||
| Inspiration | 4.2 ± 0.3 | 4.0 ± 0.2 | < 0.001 |
| Expiration | 4.3 ± 0.3 | 4.1 ± 0.3 | 0.095 |
| Skewness | |||
| Inspiration | 2.5 ± 0.4 | 2.4 ± 0.4 | 0.213 |
| Expiration | 1.4 ± 0.4 | 1.5 ± 0.5 | 0.357 |
| Kurtosis | |||
| Inspiration | 5.4 ± 2.1 | 4.8 ± 2.0 | 0.201 |
| Expiration | 0.8 ± 1.1 | 1.2 ± 1.8 | 0.253 |
DLco = diffusion capacity of lung for carbon monoxide, FEF25–75% = forced expiratory flow between 25–75%, FEV1 = forced expiratory volume in 1 second, FRCCT = functional residual capacity, FVC = forced expiratory vital capacity, HU = Hounsfield unit, MLA = mean lung attenuation, Pi10 = inner perimeter of 10 mm, RV = residual volume, TLC = total lung capacity, VC = vital capacity, %LAAE-856 = percentage of low attenuation area with CT attenuation values less than −856 HU at expiration, %LAAI-950 = percentage of low attenuation area with CT attenuation values less than −950 HU at inspiration