Table 5. Comparisons of QCT and PFT Measurements Grouped by Age.
| ≤ 40 Years (n = 28) | 41–60 Years (n = 69) | > 60 Years (n = 67) | P | |
|---|---|---|---|---|
| FVC (% predicted) | 92.0 ± 10.8 | 102.0 ± 10.6 | 101.3 ± 16.5 | < 0.001 |
| FEV1 (% predicted) | 96.7 ± 10.7 | 108.1 ± 12.9 | 112.9 ± 23.2 | < 0.001 |
| FEV1/FVC (%) | 84.4 ± 5.1 | 79.1 ± 6.0 | 77.2 ± 6.5 | < 0.001 |
| FEF25–75% (% predicted) | 98.6 ± 26.8 | 95.3 ± 22.9 | 92.5 ± 35.7 | 0.662 |
| TLC (% predicted) | 93.5 ± 13.6 | 108.8 ± 14.5 | 116.2 ± 23.6 | 0.066 |
| VC (% predicted) | 88.5 ± 3.8 | 108.7 ± 26.5 | 109.2 ± 24.5 | 0.169 |
| RV (% predicted) | 96.3 ± 46.5 | 103.0 ± 27.7 | 121.5 ± 53.6 | 0.430 |
| DLco (% predicted) | 84.4 ± 14.0 | 104.0 ± 14.1 | 90.4 ± 16.9 | 0.023 |
| TLCCT, mL | 4718.7 ± 1127.2 | 4444.2 ± 1095.9 | 4048.7 ± 1079.4 | 0.020 |
| FRCCT, mL | 2755.5 ± 789.9 | 2864.3 ± 734.8 | 2763.5 ± 828.2 | 0.729 |
| %LAAI-950 | 1.1 ± 2.7 | 0.9 ± 2.0 | 1.9 ± 3.8 | 0.137 |
| %LAAE-856 | 7.6 ± 8.8 | 16.1 ± 13.6 | 21.4 ± 17.6 | < 0.001 |
| HU 15 percentile-inspiration | -895.8 ± 25.3 | -896.3 ± 25.2 | -901.8 ± 23.6 | 0.374 |
| MLA (HU) | ||||
| Inspiration | -832.9 ± 26.4 | -830.3 ± 32.3 | -832.0 ± 28.0 | 0.917 |
| Expiration | -726.1 ± 42.9 | -752.7 ± 46.2 | -760.3 ± 44.5 | 0.005 |
| Pi10 | ||||
| Inspiration | 4.2 ± 0.3 | 4.1 ± 0.3 | 4.1 ± 0.3 | 0.735 |
| Expiration | 4.2 ± 0.3 | 4.2 ± 0.3 | 4.2 ± 0.3 | 0.256 |
| Skewness | ||||
| Inspiration | 2.5 ± 0.4 | 2.4 ± 0.4 | 2.4 ± 0.4 | 0.172 |
| Expiration | 1.3 ± 0.5 | 1.5 ± 0.5 | 1.5 ± 0.5 | 0.376 |
| Kurtosis | ||||
| Inspiration | 5.5 ± 2.1 | 5.0 ± 2.0 | 4.6 ± 1.8 | 0.165 |
| Expiration | 0.6 ± 1.1 | 1.1 ± 1.5 | 1.1 ± 1.8 | 0.277 |
DLco = diffusion capacity of lung for carbon monoxide, FEF25–75% = forced expiratory flow between 25–75%, FEV1 = forced expiratory volume in 1 second, FRCCT = functional residual capacity, FVC = forced expiratory vital capacity, HU = Hounsfield unit, MLA = mean lung attenuation, PFT = pulmonary function test, Pi10 = inner perimeter of 10 mm, QCT = quantitative computed tomography, RV = residual volume, TLC = total lung capacity, VC = vital capacity, %LAAE-856 = percentage of low attenuation area with CT attenuation values less than −856 HU at expiration, %LAAI-950 = percentage of low attenuation area with CT attenuation values less than −950 HU at inspiration