Supplementary Table 3.
Subgroup multiple logistic regression analysis of dysnatremia as independent risk factors for hospital mortality in model 2.
| Subgroup | CA-hyponatremia§ | HA-hyponatremia§ | CA-hypernatremia§ | HA-hypernatremia§ | Mixed dysnatremia§ | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | |
| Age, year | ||||||||||
| ≤65 | 2.433 (1.694–3.495) | 0.000 | 3.077 (2.216–4.273) | 0.000 | 9.953 (5.545–17.865) | 0.000 | 22.295 (14.862–33.445) | 0.000 | 18.570 (9.827–35.092) | 0.000 |
| >65 | 1.878 (1.414–2.494) | 0.000 | 2.329 (1.786–3.037) | 0.000 | 7.767 (5.146–11.724) | 0.000 | 13.665 (9.957–18.754) | 0.000 | 23.599 (15.462–36.017) | 0.000 |
| Gender | ||||||||||
| Male | 1.755 (1.335–2.308) | 0.000 | 2.219 (1.713–2.875) | 0.000 | 9.094 (5.740–14.406) | 0.000 | 18.348 (13.365–25.190) | 0.000 | 20.081 (12.820–31.454) | 0.000 |
| Female | 2.307 (1.561–3.410) | 0.000 | 3.387 (2.389–4.803) | 0.000 | 8.502 (4.900–14.752) | 0.000 | 13.847 (9.030–21.232) | 0.000 | 25.346 (14.148–45.406) | 0.000 |
| BMI, kg/m2 | ||||||||||
| <18.5 | 2.063 (0.531–8.018) | 0.296 | 0.961 (0.168–5.515) | 0.965 | – | – | 74.385 (12.840–430.910) | 0.000 | 1112.828 (35.443–34940.099) | 0.000 |
| 18.5–24.99 | 1.951 (1.543–2.4680) | 0.000 | 2.696 (2.182–3.332) | 0.000 | 8.762 (6.066–12.655) | 0.000 | 15.957 (12.260–20769) | 0.000 | 19.960 (13.854–28.758) | 0.000 |
| ≥25 | 3.595 (1.223–10.570) | 0.020 | 0.455 (0.058–3.565) | 0.454 | 9.688 (1.099–85.409) | 0.041 | 7.266 (1.712–30.840) | 0.007 | 34.163 (3.095–377.072) | 0.004 |
| Underlying diseases | ||||||||||
| Cancer | 1.368 (0.804–2.328) | 0.248 | 0.036 (0.001–1.2) | 0.063 | 19.477 (9.896–38.334) | 0.000 | 33.15 (12.192–90.129) | 0.000 | 1.368 (0.804–2.328) | 0.248 |
| Pulmonary | 2.886 (1.546–5.389) | 0.001 | 3.527 (1.571–7.919) | 0.002 | 11.744 (5.31–25.971) | 0.000 | 24.852 (7.745–79.748) | 0.000 | 2.886 (1.546–5.389) | 0.001 |
| Cardiovascular | 4.514 (2.7–7.548) | 0.000 | 6.997 (3.207–15.263) | 0.000 | 12.403 (5.67–27.133) | 0.000 | 9.718 (2.904–32.513) | 0.000 | 4.514 (2.7–7.548) | 0.000 |
| Digestive | 1.991 (0.855–4.635) | 0.110 | 21.924 (4.875–98.609) | 0.000 | 7.671 (1.914–30.755) | 0.004 | 55.185 (13.645–223.184) | 0.000 | 1.991 (0.855–4.635) | 0.110 |
| Hematological | 3.627 (1.909–6.89) | 0.000 | 4.458 (1.212–16.404) | 0.025 | 17.19 (4.915–60.119) | 0.000 | 28.916 (5.208–160.535) | 0.000 | 3.627 (1.909–6.89) | 0.000 |
| Neurological | 2.671 (1.112–6.42) | 0.028 | 8.124 (2.671–24.713) | 0.000 | 24.574 (11.16–54.11) | 0.000 | 23.028 (7.879–67.307) | 0.000 | 2.671 (1.112–6.42) | 0.028 |
| Urinary and renal | 2.579 (1.175–5.661) | 0.018 | 13.427 (4.347–41.475) | 0.000 | 20.734 (9.183–46.811) | 0.000 | 36.159 (7.867–166.184) | 0.000 | 2.579 (1.175–5.661) | 0.018 |
| Cardiothoracic surgery | 2.09 (0.875–4.994) | 0.097 | 20.563 (6.3–67.125) | 0.000 | 29.047 (12.987–64.968) | 0.000 | 18.291 (6.262–53.425) | 0.000 | 2.09 (0.875–4.994) | 0.097 |
| General surgery | 2.559 (1.084–6.039) | 0.032 | 5.917 (1.332–26.276) | 0.019 | 5.545 (1.547–19.872) | 0.009 | 6.703 (1.179–38.101) | 0.032 | 2.559 (1.084–6.039) | 0.032 |
| Others | 3.039 (1.109–8.327) | 0.031 | 11.19 (2.581–48.514) | 0.001 | 12.402 (3.918–39.254) | 0.000 | 71.597 (14.877–344.574) | 0.000 | 3.039 (1.109–8.327) | 0.031 |
| AKI | ||||||||||
| Yes | 1.666 (1.224–2.266) | 0.001 | 1.921 (1.455–2.537) | 0.000 | 10.749 (7.000–16.507) | 0.000 | 10.869 (8.026–14.720) | 0.000 | 10.983 (7.443–16.206) | 0.000 |
| No | 1.558 (1.110–2.188) | 0.010 | 1.541 (1.080–2.199) | 0.017 | 2.844 (1.391–5.817) | 0.004 | 7.200 (3.939–13.163) | 0.000 | 17.113 (6.638–44.117) | 0.000 |
| Length of hospital stay, day | ||||||||||
| ≤30 | 1.599 (1.241–2.061) | 0.000 | 1.781 (1.381–2.296) | 0.000 | 8.593 (5.808–12.712) | 0.000 | 17.738 (13.487–23.329) | 0.000 | 17.934 (11.561–27.822) | 0.000 |
| >30 | 4.548 (2.809–7.363) | 0.000 | 2.718 (1.701–4.342) | 0.000 | 5.579 (2.488–12.509) | 0.000 | 4.680 (2.461–8.902) | 0.000 | 10866 (5.760–20.499) | 0.000 |
§
Normonatremia as the reference.
CA – community-acquired; HA – hospital-acquired; BMI – body mass index; AKI – acute kidney injury; OR – odds ratio; CI – confidence interval.