Table 4.
Summary of the antimicrobial resistance features of Shigella sonnei 75/02.
| Antibiotic | MIC-value (mg/l) | Identified and *putative resistance gene(s) | Location | Homologs (GenBank no.) | |
|---|---|---|---|---|---|
| S. sonnei 75/02 | E. coli MG1655 | ||||
| Amp | >100 | ≤ 50 | blaTEM−52 | p75/02_4 | pESBL-117 (CP008734.1.1) |
| Beta lactamase class C | chromosome, 534,200–535,492 | S. sonnei Ss046 (CP000038.1) S. sonnei FDAARGOS_90 (CP014099.1) S. sonnei FORC_011 (CP010829.1) S. sonnei 53G (HE616528.1) | |||
| ampC | chromosome, 2,480,937–2,481,804 | S. sonnei Ss046 (CP000038.1) S. sonnei FDAARGOS_90 (CP014099.1) S. sonnei FORC_011 (CP010829.1) S. sonnei 53G (HE616528.1) | |||
| Sm | >60 | ≤ 3.75 | aadA1 | class I integron, chromosome 1,987,080–1,987,868 | S. sonnei FDAARGOS_90 (CP014099.1) S. sonnei FORC_011 (CP010829.1) |
| Tet | >40 | ≤ 2.5 | acrAB* | chromosome, 3,175,127–3,178,276 | S. sonnei Ss046 (CP000038.1) S. sonnei FDAARGOS_90 (CP014099.1) S. sonnei FORC_011 (CP010829.1) S. sonnei 53G (HE616528.1) |
| Tmp | >128 | ≤ 4 | dfrA1 | class I integron, chromosome, 1,988,548–1,989,018 | S. sonnei FDAARGOS_90 (CP014099.1) S. sonnei FORC_011 (CP010829.1) |
| Sul | >128 | >128 | acrAB* | chromosome, 3,175,127–3,178,276 | S. sonnei Ss046 (CP000038.1) S. sonnei FDAARGOS_90 (CP014099.1) S. sonnei FORC_011 (CP010829.1) S. sonnei 53G (HE616528.1) |
| Cm | 7.5 | ≤ 3.75 | acrAB* | chromosome, 3,175,127–3,178,276 | S. sonnei Ss046 (CP000038.1) S. sonnei FDAARGOS_90 (CP014099.1) S. sonnei FORC_011 (CP010829.1) S. sonnei 53G (HE616528.1) |
Amp, ampicillin; Sm, streptomycin; Tet, tetracycline; Tmp, trimethoprim; Sul, sulfometoxazole; Cm, chloramphenicol, MIC, minimal inhibitory concentration.
*
Most likely gene associated with the resistance phenotypes.