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. 2017 May 30;11:152. doi: 10.3389/fncel.2017.00152

Figure 2.

Figure 2

Reduction of mTOR activity increased protein levels of potassium channels and their associated protein. Intraperitoneal (i.p.,) administration of rapamycin (Rapa; 1 mg/kg; 1 h), an mTOR inhibitor, in mice (A) reduced mTOR activity (DMSO = 1.00 ± 0.07; Rapa = 0.71 ± 0.02), but increased (B) Kv1.1 (DMSO = 1.00 ± 0.09; Rapa = 1.88 ± 0.33), (C) Kv1.2 (DMSO = 1.00 ± 0.01; Rapa = 1.21 ± 0.07), and (D) Kvβ2 (DMSO = 1.00 ± 0.01; Rapa = 1.40 ± 0.03) as measured by densitometry analysis. P-mTOR and mTOR denote phosphorylated mTOR and total mTOR, respectively. Representative images and quantification (average ± SEM) are shown. N = 4 (DMSO) and 3 (Rapa) animals. Statistics: Student’s t-test; *p < 0.05, **p < 0.01, ***p < 0.001.