Figure 3.

Pan-genome structure and function of P. multocida. (A) A pan-genome map containing 2,966 OG clusters in all P. multocida genomes detected by Proteinortho (Lechner et al., 2011). Each block strands for a gene: green for presence and gray for absence. (B) COG-based binning of core genes, dispensable genes, and strain-specific genes. The abscissa denotes different COG functional categories. The ordinate denotes the proportion of genes in each COG category and details are summarized in Table S3. Two COG functional categories (“RNA processing and modification” and “Cell motility”) including only one OG are not displayed, as well as the genes encoding proteins without homologs in the COG collection. Significant enrichment of gene occurrence in the individual category is marked by asterisks (FDR < 0.001; Chi-square test).