Figure 2.

INT131 improves insulin resistance similar to rosiglitazone in DIO mice. (A) Oral glucose tolerance test (OGTT) were performed on male DIO mice after treatment with vehicle, 10 mg kg⁻¹ rosiglitazone (RSG) or 30 mg kg⁻¹ INT131 (INT131 30). Glucose (1 g kg⁻¹) was administered by gavage to 12-h-fasted DIO mice. (B) Area under the curve for OGTT. (C) FBG, (D–G) body weight, iWAT, BAT, and liver index. (H–J) Serum concentrations of MCP-1, IL-6, RANKL, ACTH, and adiponectin in the DIO mice. MC, model control; n = 5–6 for each group. Multiple comparisons were performed with one-way ANOVA followed by Tukey's multiple comparison tests. Data are mean ± SE. ^*p < 0.05 compared with the vehicle. ^#P < 0.05 compared with normal mice.