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. 2017 May 30;8:317. doi: 10.3389/fphar.2017.00317

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Copyright © 2017 Xie, Chen, Zhang, Yuan, Xu, Zheng, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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INT131 upregulates BAT-selective and adipogenic gene expression in skeletal muscle of DIO mice. (A) Expression of BAT-selective and adipogenic genes in skeletal muscle of DIO and (B) db/db mice. (C) Expression of BAT-selective and adipogenic genes and (D) muscle-specific genes in C2C12 cells; gene expression assay in the C2C12 cells were detected after treatment with 10 μM of RSG or INT131 for 5 days. n = 3 for each group. Multiple comparisons were performed with one-way ANOVA followed by Tukey's multiple comparison tests. Data are mean ± SD. ^*p < 0.05, ^**p < 0.01 compared with the vehicle.