Figure 1.

EGFR mediated immunoescape. EGFR stimulation induces activation of phosphatase SHP2 which decreases phosphorylation of STAT1 and subsequently expression of HLA class I and APM components. Additionally, EGFR mediated activation of JAK2-STAT1 induces expression of PD-L1. EGFR stimulation induces activation of STAT3 and production of immunosuppressive cytokines such as IL-10, VEGF and TGFβ which in turn induce Treg expansion and inhibition of CTL activation. Overall, EGFR signaling mediates downregulation of signal 1 and upregulation of suppressive signals 2 and 3, favoring escape from effector T cell recognition.