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Histopathology of spleens of immunized mice and control mice after challenge with F. novicida. There is necrosis and fibrin accumulation surrounded by neutrophils and cellular debris within the red pulp of spleens of control mice (A). In contrast, there is moderate to marked lymphoid hyperplasia characterized by nodular aggregates of lymphocytes, but no evidence of necrosis or neutrophilic inflammation in the spleens of immunized mice (B). H&E stain, bar = 20 μm.
