Table 2.
CLC glycosylation locus in F. tularensis subspecies.
| F. tularensis subsp. novicida ORF | Size (bp) | Protein producta | F. tularensis subsp. holarctica LVS ORF | F. tularensis subsp. tularensis schuS4 ORF | % Sequence Identity to type A |
|---|---|---|---|---|---|
| FTN_1221 | 669 | D-ribulose-phosphate 3-epimerase | FTL_1432 | FTT_0789 | 98 |
| FTN_1220 | 1395 | Glycosyltransferase | FTL_1431 | FTT_0790 | 97 |
| FTN_1219 | 1020 | UDP-glucose 4-epimerase | FTL_1430 | FTT_0791 | 97 |
| FTN_1218 | 1230 | Glycosyltransferase | FTL_1429 | FTT_0792 | 97 |
| FTN_1217 | 1689 | ATP-binding membrane transporter | FTL_1428 | FTT_0793 | 98 |
| Not present | 1287 | Hypothetical protein | FTL_1427 | FTT_0794 | NAb |
| Not present | 684 | Hypothetical protein | FTL_1426 | FTT_0795 | NA |
| Not present | 762 | Hypothetical protein | FTL_1425 | FTT_0796 | NA |
| FTN_1216 | 744 | Hypothetical protein with methyltransferase domain | Not present | Not present | NA |
| FTN_1215 | 1161 | Capsule polysaccharide export protein | Not present | Not present | NA |
| FTN_1214 | 960 | Galactosyltransferase | FTL_1424 | FTT_0797 | 98 |
| FTN_1213 | 1008 | Galactosyltransferase | FTL_1423 | FTT_0798 | 97 |
| FTN_1212 | 1014 | Mannosyltransferase | FTL_1422 | FTT_0799 | 96 |
| FTN_1211 | 663 | Haloacid dehalogenase | FTL_1421 | FTT_0800 | 98 |
a
F. novicida homologs to the F. tularensis Type A and LVS CLC glycosylation locus. Two genes are present in F. novicida that are not found in the F. tularensis locus. There are three genes in the F. tularensis CLC glycosylation locus that are not present in the F. novicida locus: FTT0794, FTT0795, and FTT0796; all three genes encode for hypothetical proteins.
b
NA, Not applicable.