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. 2017 May 30;8:349. doi: 10.3389/fphys.2017.00349

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Copyright © 2017 Schmitz, Schelleckes, Nedele, Thorwesten, Klose, Lenders, Krüger, Brand and Brand.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-126 levels were increased in response to exercise in the LIT and proHIIT group post-training. After the 4-week training intervention, a significant increase of acute miR-126 levels was detected post-exercise (A) in the LIT group and (C) in the proHIIT group (run 7), while miR-126-3p levels were still reduced in (B) the HIIT group (run 4). Elevated miR-126-5p levels were only detected during exercise (run 4) in the proHIIT group. miRNA levels at follow-up were analyzed directly after the last run (run 4) and after 3 min of recovery (post-exercise) in the HIIT group. In the proHIIT group, miRNA levels were analyzed during the exercise (run 4) and directly after the exercise (run 7, post-exercise). Data are represented as mean ± SD. P-values are rest vs. post-exercise using ANOVA. ^*p < 0.05; ^**p < 0.01.