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. 2017 May 30;8:372. doi: 10.3389/fphys.2017.00372

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Copyright © 2017 Mitsiadis, Catón, Pagella, Orsini and Jimenez-Rojo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proliferation of dental pulp cells correlates with Notch2 protein expression in the apex of injured molar teeth. BrdU in red color, Notch2 (N2) staining in green color. (A) Proliferating dental pulp cells in intact teeth. (B) Proliferating pulp cells in injured teeth. Note that cell proliferation increases upon injury. (C–E) Confocal microscope analysis showing co-expression of BrdU (C) and Notch2 (D) in the apical part of the pulp after merging of the pictures (E). Scale bars: 50 μm (A–E).