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. 2017 May 30;8:372. doi: 10.3389/fphys.2017.00372

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Copyright © 2017 Mitsiadis, Catón, Pagella, Orsini and Jimenez-Rojo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the suggested relationship between Notch signaling, dental pulp stem cell niches, and their activation upon tooth injury. (A) Potential stem/progenitor cells within the dental pulp at the crown level. Cells related to perivascular niches and odontoblast progenitors (i.e., sub-odontoblastic cells) will express a specific Notch receptor after dental injury at the crown level. (B) A model summarizing the cellular events after dental injury. Cavity preparation activates stem cell niches located in different parts of the dental pulp (light blue asterisks). Stem/progenitor cells start to migrate toward the injury site (blue arrows) and once on place might differentiate into odontoblast-like cells and participate to the formation of reparative dentin. Abbreviations: d, dentin; DPSC, dental pulp stem cells; HSC, hematopoietic stem cells; o, odontoblasts; p, pulp.