Figure 4.

Schematic presentation of amyloidogenic pathway and formation of amyloid-β (Aβ) in AD. The amyloidogenic process is initiated by the enzymatic breakdown of amyloid precursor protein (APP) by beta amyloid cleaving enzyme (BACE1) called beta secretase at beta site. This is followed by catalytic cleavage of APP by gamma secretase to form non-soluble protein or Aβ. This Aβ accumulation in the neurons leading to impairment in the neurotransmission and neurodegeneration. EOs can inhibit the activity of BACE1 to hamper the Aβ load.