Table 2. Differences in baseline systolic BP and SBP variability and percentage change in each measure 8 days after starting or increasing the dose of each class of antihypertensive drug.

Treatment groups are defined as low variability drugs (CCB or diuretic), high variability drugs (RASi or beta-blockers) or a combination of a RASi and a diuretic. SD=standard deviation; CV=coefficient of variation; rCV=residual CV about a 5 day moving average. Mean values are compared by ANOVA. *p<0.05; ** p<0.01; *** p<0.001.

	3-10 days before intervention				% change >8 days after intervention
	High	Combined	Low		High	Combined	Low
	62	50	178	p-val	62	49	178	P-val
All measures
Mean	129.5	127.7	132.4	0.038*	-1.9	-2.4	-3	0.39
Minimum	110.2	109.4	112.3	0.26	-1.6	-3.6	-1.3	0.26
Maximum	149.4	147.2	154.2	0.017*	-1.0	-1.0	-4.6	0.001**
rCV	7.9	8	7.9	0.98	7.8	6.9	-4	0.015*
Morning
Mean	131.9	129.9	134.3	0.13	-1.6	-3	-3.7	0.09
Minimum	120.4	117.5	122.1	0.09	-1.9	-1.7	-2.5	0.76
Maximum	143.7	142.1	147.2	0.13	-0.7	-2.0	-4.8	0.001**
rCV	5.3	5.9	5.6	0.62	38.3	7	3.6	0.002**
Diurnal SD	9.8	9.1	10.4	0.23	-0.6	0.6	-1.9	0.92
Diurnal CV	7.5	7.4	7.8	0.64	2.0	3.8	1.0	0.92