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Coverage of histone peptides with LC-MS/MS. The peptides indicated in bold are the ones that were detected and analyzed. With this LC-MS/MS method almost all acetylation sites in histone H3 and H4 can be studied. In both histones 2 sites are being missed due to the fact that the peptides containing these lysines are either very small or large, or do not trap well on the LC column. Altogether, most of the important lysines in the N-terminal tails of these histones can be detected.
