Figure 2.

Crossover design. Schematic representation of the study design. All participants received both CT and AC but in a different order: after randomization in the two arms of the study (arm A, arm B). Participants in arm A received first CT and then AC, and in arm B first AC and then CT. Neuroimaging and cognitive outcomes were acquired at baseline (M0), after three months at the switch between treatments (M3), and after six months at the end of the study (M6). Outcomes acquired pre-CT and post-CT and pre-AC and post-AC of both arms were grouped before the statistical analyses.