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. 2017 Apr 29;7(5):50. doi: 10.3390/brainsci7050050

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Changes in DMN. Left panel: Effect size of mSFG (region in blue in the left central rendering) functional connectivity changes of the significant interaction between aMCI and HE and treatment, showing a greater functional connectivity decrease in aMCI vs. HE after the ΔCT (white columns) vs. ΔAC (lined columns). Right top panel: Effect size of PCu (region in hot color in the central render) functional connectivity changes, showing the significant main effect of the whole sample of participants between ΔCT (white columns) > ΔAC (lined columns). Right bottom panel: Effect size of the MTL (region in blue in the right central rendering) functional connectivity changes, showing the significant main effect in mAD sample between ΔCT (white columns) < AC (lined columns). Abbreviations: ΔCT = cognitive training; ΔAC = active control condition; HE = healthy elderly; aMCI = amnestic Mild Cognitive Impairment; mAD = mild Alzheimer’s Disease; mSFG = medial superior frontal gyrus; PCu = precuneus; MTL = medial temporal lobe.