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. 2017 Apr 29;7(5):50. doi: 10.3390/brainsci7050050

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Changes in connectomics. Lateral panels. Significant changes after CT in betweenness centrality (top row) and in coupling strength between couples of nodes (bottom row) in mAD patients (left panel) and subjects with aMCI (right panel). In red are the increases and in blue are the decreases of the metrics. Central panel. Scatter plots with effect size of individual subjects superimposed calculated effect by dividing the difference between ΔCT and ΔAC by their pooled standard deviation [69], for significant regions and edges. Abbreviations: mAD = mild Alzheimer’s disease; aMCI = Mild Cognitive Impairment; CT = cognitive training; l = left hemisphere; r = right hemisphere; AC = anterior cingulum; OFG = Orbito frontal gyrus; V = vermis; H = hippocampus; Pa = parahippocampal gyrus; C = calcarine cortex; T = thalamus; GP = globus pallidus; Cu = cuneus; Ce = cerebellum.