Table 4.
Connectomics results. Mean metrics/edges values (SD).
| Method | Group | CT Effect | Measure | Brain Area | Side | ΔCT (Post-Pre) | ΔAC (Post-Pre) | T | p (2-Tailed) | N | r | |
| BCT | mAD | (post CT > pre CT) | Betweenness centrality | Anterior cingulum | R | 8.26 (10.66) | −0.91 (14.46) | 51 | 0.044 | 20 | 0.32 | |
| aMCI | (post CT > pre CT) | Betweenness centrality | Orbito-frontal region | R | 7.77 (5.25) | −2.39 (8.52) | 21 | 0.009 | 17 | 0.45 | ||
| aMCI | (pre CT > post CT) | Betweenness centrality | Cerebellum-Vermis | −10.7 (10.28) | 6.61 (8.53) | 155 | <0.001 | 17 | −0.62 | |||
| Method | Group | CT Effect | Edge | ΔCT (Post-Pre) | ΔAC (Post-Pre) | T | p (2-Tailed) | N | r | |||
| Brain Area | Side | Brain Area | Side | |||||||||
| NBS | mAD | (post CT > pre CT) | Calcarine cortex | L | Hippocampus | L | 0.19 (0.23) | −0.16 (0.27) | 21 | 0.002 | 20 | 0.5 |
| Calcarine cortex | R | Parahippocampal gyrus | L | 0.22 (0.23) | −0.16 (0.27) | 17 | 0.001 | 20 | 0.52 | |||
| Calcarine cortex | R | Hippocampus | L | 0.19 (0.18) | −0.11 (0.26) | 22 | 0.002 | 20 | 0.49 | |||
| aMCI | (pre CT > post CT) | Thalamus | L | Hippocampus | L | −0.17 (0.17) | 0.05 (0.34) | 122 | 0.031 | 17 | −0.37 | |
| Thalamus | R | Globus pallidus | R | −0.17 (0.18) | 0.13 (0.18) | 144 | 0.001 | 17 | −0.55 | |||
| Cerebellum | R | Cuneus | R | −0.2 (0.2) | 0.13 (0.29) | 130 | 0.011 | 17 | −0.43 | |||
Abbreviations: aMCI = amnestic mild cognitive impairment subjects; mAD = mild Alzheimer’s Disease patients; CT = cognitive training; AC = active control condition; L = left; R = right; T = T statistic for the Wilcoxon test comparing ΔCT and ΔAC of the same subjects; p (2-tailed) = p-value 2-tailed for the Wilcoxon test; N = number of subjects in the Wilcoxon test analysis; r = effect size derived from T statistic converted in z-scores/root square of the number of total observations.