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MT-related pathways induced by HGF/cMet in cancer cells. HGF/cMet activates multiple pathways, including EB1 and +TIPs recruitment to MT ends, tankyase, and stathmine-mediated stabilization of MT. Meanwhile, MT mediate WAVE2 and KIF5B translocation to the lamellipodia in response to HGF. Microfilaments and MT share a common regulator, EB1, which also regulates actin filament dynamics in a Rac1 dependent-manner.
