Table 1.

Association of microRNAs with genetic drivers, therapeutically-targeted molecules, and carcinogens.

Various Features	MicroRNA
Genetic drivers
EGFR mutation	Overexpression: miR-184, miR-339-3p, miR-148a*, miR-224*, miR-452, miR-450a, miR-423-3p,          miR-654-5p, miR-532-5p, miR-3607-5p, miR-28-3p, miR-30d*, miR-532-3p,          miR-500a*, miR-502-3p, miR-605 [28] Underexpression: miR-492 [28]
KRAS mutation	Overexpression: miR-100 [28] Underexpression: miR-371-5p, miR-564 [28]
ALK rearrangement	Overexpression: miR-1343-3p [29] Underexpression: miR-671-3p, miR-103a-3p, let-7e, miR-342-3p [29]
Therapeutically-targeted molecules
PD-L1 (CD274)	MiR-34 targets PD-L1 [30]
B7-H3 (CD276)	MiR-29a targets B7-H3 [31]
TROP2 (TACSTD2)	MiR-125b-1 targets TROP2 [32]
Carcinogens
Cigarette smoke	Overexpression: miR-210 [33] Underexpression: miR-342, miR-151, miR-501-3p, miR-29b, miR-30d, miR-497, miR-222,          miR-505, miR-34b, miR-500, miR-99a-3p [33]
Asbestos	Overexpression: miR-148b, miR-374a, miR-24-1*, let-7d, let-7e, miR-199b-5p, miR-331-3p,          miR-96 [34] Underexpression: miR-939, miR-671-5p, miR-605, miR-1224-5p, miR-202 [34]

In microRNA biogenesis, one strand of microRNA duplexes is picked to function as a mature microRNA and loaded into the RNA-induced silencing complex (RISC), whereas the partner microRNA* is conversely degraded. The “*” notation indicates the passenger strand of the duplex, which could also function as listed.