Table 1.

DRB1-DQA1-DQB1 haplotype frequencies in controls and early-onset type 1 diabetes (T1D) patients and corresponding odds ratios to develop early-onset T1D.

DRB1*	DQA1*	DQB1*	Controls	T1D Patients	Odds Ratio (CI)	p
			n (%)	n (%)
01:01	01:01	05:01	3582 (9.2)	32 (6.9)	0.73 (0.51; 1.05)	0.087
01:02	01:01	05:01	471 (1.2)	5 (1.1)	0.89 (0.39; 2.08)	0.795
03:01	05:01	02:01	4089 (10.5)	155 (33.3)	4.27 (3.51; 5.17)	<0.001
04:01	03:01	03:02	1801 (4.6)	149 (32.0)	9.73 (7.96; 11.86)	<0.001
04:01	03:01	03:01	989 (2.5)	3 (0.6)	0.25 (0.08; 0.71)	0.010
04:02	03:01	03:02	391 (1.0)	12 (2.6)	2.62 (1.46; 4.63)	<0.001
04:03	03:01	03:02	271 (0.7)	1 (0.2)	0.31 (0.03; 1.69)	0.214
04:04	03:01	03:02	809 (2.1)	19 (4.1)	2.01 (1.28; 3.17)	0.003
04:05	03:01	02:02	36 (0.1)	3 (0.6)	7.03 (2.26; 21.65)	<0.001
04:05	03:01	03:02	111 (0.3)	8 (1.7)	6.13 (2.94; 12.36)	<0.001
07:01	02:01	02:02	3408 (8.7)	5 (1.1)	0.11 (0.05; 0.26)	<0.001
07:01	02:01	03:03	1411 (3.6)	1 (0.2)	0.06 (0.01; 0.31)	<0.001
08:01	04:01/02*	04:02	971 (2.5)	22 (4.7)	1.95 (1.25; 2.97)	0.002
11:01	05:01	03:01	2987 (7.6)	3 (0.6)	0.08 (0.03; 0.22)	<0.001
11:04	05:01	03:01	1363 (3.5)	1 (0.2)	0.06 (0.01; 0.32)	<0.001
12:01	05:01	03:01	757 (1.9)	4 (0.9)	0.44 (0.17; 1.11)	0.092
13:01	01:03	06:03	2737 (7.0)	8 (1.7)	0.23 (0.11; 0.45)	<0.001
13:02	01:02	06:04	1441 (3.7)	12 (2.6)	0.69 (0.39; 1.20)	0.205
13:03	05:01	03:01	542 (1.4)	1 (0.2)	0.15 (0.02; 0.83)	0.031
14:01/54*	01:01	05:03	726 (1.9)	0 (0.0)	0.00 (0; 0.05)	<0.001
15:01	01:02	06:02	4634 (11.9)	0 (0.0)	0.00 (0; 0.39)	0.003
16:01	01:02	05:02	1014 (2.6)	13 (2.8)	1.08 (0.61; 1.86)	0.792
others			4547 (11.6)	9 (1.9)