Figure 4.

A model for how LCA-driven changes in different aspects of mitochondrial functionality modulate activities of a discrete set of transcription factors that are integrated into the partial mitochondrial dysfunction (PMD) and oxidative stress (OS) signaling pathways. These factors then orchestrate an establishment of an antiaging transcriptional program for numerous nuclear genes. These genes encode various cellular proteins that play essential roles in regulating longevity of chronologically aging yeast. See text for more details. ΔΨ: the mitochondrial membrane potential. Other abbreviations are provided in the legend for Table 1.