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Influence of EP receptor agonists on the release of TNFα and IL-10 from platelet-stimulated human monocytes. Human monocytes were incubated alone or with untreated platelets and the respective EP agonist concentrations for 3 hours (400 nM ONO-Di-004, 170 nM butaprost, 10 nM sulprostone, 5 nM L-902,688, 1 μM PGE2). TNFα (a) or IL-10 (b) were determined by ELISA. Data are presented as mean ± SEM from 4 experiments. One-way ANOVA/Bonferroni ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.002.
