Table 1.
Groups | Animal | Number | Pathogen | Dosagea | Method | Clinical signs | Dead |
---|---|---|---|---|---|---|---|
ml | |||||||
1 | Rabbit | 3 | mRHDV | 1 | Intramuscular injection | + + + | 3/3 (100%) |
2 | Rabbit | 3 | RHDV (JX/CHA/97) | 1 | Intramuscular injection | + + + | 3/3 (100%) |
3 | Rabbit | 3 | PBS | 1 | Intramuscular injection | − − − | 0/3 (0) |
4 | Mouse | 5 | mRHDV | 0.1 | Intramuscular injection | − − − − − | 0/5 (0) |
5 | Mouse | 5 | RHDV (JX/CHA/97) | 0.1 | Intramuscular injection | − − − − − | 0/5 (0) |
6 | Mouse | 5 | PBS | 0.1 | Intramuscular injection | − − − − − | 0/5 (0) |
a mRHDV, 1 × 104.3 TCID50/ml; RHDV (JX/CHA/97), 1 × 103 LD50/ml. +, positive; −, negative.