Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of two-step reaction in Imd Lys-63-polyubiquitination. Imd is Lys-63-polyubiquitination by E2s. Imd is mono-ubiquitinated by Ubc5 and subsequently elongated with Lys-63 linkage by Ubc13-Uev1a. Alternatively, Ubc5 alone is able to catalyze both mono-ubiquitination and chain elongation with unknown linkage.
