Figure 3.

Dose-response kinetics of uptake. A, HDL-[³H]CE. B, HDL-[¹²⁵I]apoAI. C, HDL- [¹²⁵I]apoAII. Dose-response data were fitted to a hyperbolic function, i.e. y = ax/(b + x), where x is HDL-protein concentration, y is the radiolabel uptake, a is the maximum uptake (V_max), and b is K_m, the HDL-protein concentration at 50% of V_max. The catalytic efficiency E = (V_max/K_m). Data points are the mean ± S.D. for n = 6 for CE and n = 3 for apolipoprotein uptake. All data points have error bars, but some are not visible because they are smaller than the symbols.