Table 2.

Comparison of semiquantitative metabolite level in the central adiposity gain group versus the stable weight and adiposity group: Metabolites with a nominal P < 0.05

Metabolite	Incident central adiposity*	Stable adiposity†	Nominal P value	FDR Q-value	Higher usual glycemia‡	Lower usual glycemia§	Nominal P value	FDR Q-value
Erythritol	0.1395	0.0104	0.0004	0.0421	0.277	0.012	1.51E-06	0.00015
Fructose	0.0587	0.0271	0.0064	0.2208	0.050	0.116	0.0006	0.02770
1742¶	0.0184	0.0079	0.0060	0.2171
1297¶	0.0097	0.0135	0.0120	0.3115
2470¶	0.0089	0.0060	0.0308	0.5323
Octadecanoic acid					0.203	0.284	0.0227	0.41392
Lactic acid					1.987	2.721	0.0233	0.41789
Glycerol					0.140	0.181	0.0260	0.43348
Valine					0.436	0.350	0.0430	0.49758
1175¶					0.094	0.154	0.0468	0.50685
2278¶					0.096	0.117	0.0471	0.50754
Leucine					0.216	0.159	0.0475	0.50845

Metabolite semiquantitative findings are reported for the optimized assay, which validated results based on the nontargeted assay.

^*Defined as change in three indicators (weight increase > 0.5 kg, DXA truncal adiposity increase > 200 g, and waist circumference increase > 0.5 cm; n = 66).

^†Defined as minimal change in three indicators (weight, DXA truncal adiposity, and waist circumference; n = 16).

^‡Defined as top 25% of baseline HbA1c [n = 21; HbA1c > 5.05%, mean = 5.66% (SD = 0.18)].

^§Defined as bottom 10% of baseline HbA1c [n = 7; HbA1c < 4.92%, mean = 4.80% (SD = 0.084)].

^¶Unidentified metabolites represented with their corresponding retention indices.