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Uricase inhibition in mice exacerbates joint inflammation in a model of acute gout arthritis. Macroscopic (A) and microscopic (B) scores of the knees in mice treated with vehicle control or oxonic acid + uric acid following i.a. injection of MSU + C16. Histology (H&E staining) of joints treated with MSU + C16 in control (C) and oxonic acid (D) mice. (A) 10 knees per group, Mann–Whitney, ***P < 0.001. (B) 5 knees per group, Mann–Whitney, *P < 0.05.
