Table S1.
Differential expression analysis in uric acid samples compared with control conditions
| ENSEMBL gene D | Name | Associated gene name | Fold-change | Log2 fold-change | P | Adjusted P |
| ENSG00000196460 | Hypothetical protein LOC731220 | RFX8 | 7.828883982 | 2.968806664 | 9.31E-08 | 0.000501603 |
| ENSG00000125538 | Interleukin 1, beta | IL1B | 6.964252923 | 2.799968599 | 6.24E-05 | 0.045243847 |
| ENSG00000148737 | Transcription factor 7-like 2 (T-cell specific, HMG-box) | TCF7L2 | 5.290478721 | 2.403398274 | 2.96E-05 | 0.027957091 |
| ENSG00000106089 | Syntaxin 1A (brain) | STX1A | 4.860235491 | 2.281026218 | 1.28E-05 | 0.01615319 |
| ENSG00000169429 | Interleukin 8 | IL8 | 4.251778875 | 2.088066568 | 6.51E-06 | 0.009816684 |
| ENSG00000108688 | Chemokine (C–C motif) ligand 7 | CCL7 | 3.884742518 | 1.957818979 | 5.30E-07 | 0.001665109 |
| ENSG00000163814 | CUB domain containing protein 1 | CDCP1 | 3.8430716 | 1.942259856 | 1.17E-06 | 0.002766214 |
| ENSG00000132965 | Arachidonate 5-lipoxygenase-activating protein | ALOX5AP | 3.091663552 | 1.628383328 | 3.30E-06 | 0.005933258 |
| ENSG00000135318 | 5′-nucleotidase, ecto (CD73) | NT5E | 3.033587692 | 1.601025016 | 7.84E-07 | 0.002275635 |
| ENSG00000185022 | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | MAFF | 2.840509574 | 1.506149765 | 7.21E-05 | 0.050348895 |
| ENSG00000112715 | Vascular endothelial growth factor A | VEGFA | 2.693852556 | 1.429670889 | 5.64E-05 | 0.042515061 |
| ENSG00000108691 | Chemokine (C–C motif) ligand 2 | CCL2 | 2.627520301 | 1.393701911 | 3.23E-05 | 0.02972007 |
| ENSG00000074416 | Monoglyceride lipase | MGLL | 0.362661618 | −1.463304029 | 5.43E-05 | 0.041807142 |
| ENSG00000104763 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | ASAH1 | 0.356794446 | −1.486834938 | 3.65E-05 | 0.031977329 |
| ENSG00000138642 | Hect domain and RLD 6 | HERC6 | 0.352987591 | −1.502310628 | 1.02E-05 | 0.013787693 |
| ENSG00000185432 | Methyltransferase like 7A | METTL7A | 0.318666116 | −1.649882471 | 7.68E-06 | 0.010726304 |
| ENSG00000019582 | CD74 molecule, major histocompatibility complex, class II invariant chain | CD74 | 0.314002709 | −1.67115109 | 4.49E-05 | 0.037622658 |
| ENSG00000171115 | GTPase, IMAP family member 8 | GIMAP8 | 0.306271203 | −1.707118371 | 2.23E-05 | 0.023904018 |
| ENSG00000164125 | Chromosome 4 ORF 18 | FAM198B | 0.305061574 | −1.712827628 | 7.50E-06 | 0.010726304 |
| ENSG00000136634 | Interleukin 10 | IL10 | 0.299402731 | −1.739840716 | 5.40E-05 | 0.041807142 |
| ENSG00000145703 | IQ motif containing GTPase activating protein 2 | IQGAP2 | 0.292308919 | −1.774434246 | 2.02E-05 | 0.022398402 |
| ENSG00000196743 | GM2 ganglioside activator | GM2A | 0.289258816 | −1.789567166 | 2.18E-06 | 0.004322456 |
| ENSG00000074964 | Rho guanine nucleotide exchange factor (GEF) 10-like | ARHGEF10L | 0.279086377 | −1.841216393 | 1.17E-06 | 0.002766214 |
| ENSG00000115896 | Phospholipase C-like 1 | PLCL1 | 0.27442808 | −1.865499987 | 2.34E-05 | 0.023904018 |
| ENSG00000158473 | CD1d molecule | CD1D | 0.270697697 | −1.885245479 | 4.75E-05 | 0.038941898 |
| ENSG00000014257 | Acid phosphatase, prostate | ACPP | 0.261254237 | −1.936473658 | 3.94E-05 | 0.033803606 |
| ENSG00000123836 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | PFKFB2 | 0.261197926 | −1.936784651 | 2.82E-05 | 0.027432543 |
| ENSG00000105612 | DNase II, lysosomal | DNASE2 | 0.256812983 | −1.961209954 | 5.36E-06 | 0.008804521 |
| ENSG00000110077 | Membrane-spanning 4-domains, subfamily A, member 6A | MS4A6A | 0.244247792 | −2.033582573 | 1.07E-06 | 0.002766214 |
| ENSG00000137965 | IFN-induced protein 44 | IFI44 | 0.239462685 | −2.062127232 | 2.32E-06 | 0.004369454 |
| ENSG00000111331 | 2'-5′-oligoadenylate synthetase 3, 100 kDa | OAS3 | 0.23849616 | −2.067962058 | 1.42E-09 | 1.79E-05 |
| ENSG00000242498 | Actin-related protein 2/3 complex inhibitor | C15orf38 | 0.231719067 | −2.109551332 | 5.87E-05 | 0.043425999 |
| ENSG00000106066 | Carboxypeptidase, vitellogenic-like | CPVL | 0.230554672 | −2.116819196 | 1.23E-07 | 0.000580282 |
| ENSG00000185909 | Kelch domain containing 8B | KLHDC8B | 0.226269032 | −2.14388895 | 3.53E-05 | 0.031745009 |
| ENSG00000137841 | Phospholipase C, beta 2 | PLCB2 | 0.224149991 | −2.157463652 | 5.64E-08 | 0.000398307 |
| ENSG00000187554 | Toll-like receptor 5 | TLR5 | 0.223855507 | −2.159360283 | 2.34E-05 | 0.023904018 |
| ENSG00000126351 | Thyroid hormone receptor, alpha [erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian] | THRA | 0.217448782 | −2.201252467 | 4.33E-07 | 0.001484985 |
| ENSG00000112799 | Lymphocyte antigen 86 | LY86 | 0.209726208 | −2.253420939 | 2.08E-07 | 0.000782856 |
| ENSG00000111335 | 2'-5′-oligoadenylate synthetase 2, 69/71 kDa | OAS2 | 0.189865215 | −2.396952481 | 5.34E-05 | 0.041807142 |
| ENSG00000157168 | Neuregulin 1 | NRG1 | 0.181321359 | −2.463379217 | 1.06E-05 | 0.013791558 |
| ENSG00000010610 | CD4 molecule | CD4 | 0.179535508 | −2.477658891 | 6.50E-09 | 6.13E-05 |
| ENSG00000110079 | Membrane-spanning 4-domains, subfamily A, member 4 | MS4A4A | 0.177332037 | −2.495474897 | 6.21E-06 | 0.009764507 |
| ENSG00000242574 | Major histocompatibility complex, class II, DM beta | HLA-DMB | 0.176548141 | −2.501866465 | 1.78E-06 | 0.003950855 |
| ENSG00000136689 | Interleukin 1 receptor antagonist | IL1RN | 0.165868925 | −2.591884463 | 1.85E-05 | 0.021101038 |
| ENSG00000088827 | Sialic acid binding Ig-like lectin 1, sialoadhesin | SIGLEC1 | 0.133775145 | −2.902118 | 6.49E-05 | 0.046181687 |
| ENSG00000095970 | Triggering receptor expressed on myeloid cells 2 | TREM2 | 0.124222742 | −3.008998781 | 1.66E-07 | 0.000695424 |
| ENSG00000178199 | Zinc finger CCCH-type containing 12D | ZC3H12D | 0.09259206 | −3.432967709 | 5.37E-06 | 0.008804521 |
| ENSG00000019991 | Hepatocyte growth factor (hepapoietin A; scatter factor) | HGF | 0.082874408 | −3.592929523 | 7.28E-12 | 2.75E-07 |
| ENSG00000180767 | Carbohydrate (chondroitin 4) sulfotransferase 13 | CHST13 | 0.080061474 | −3.642748007 | 1.40E-05 | 0.01701873 |
| ENSG00000136235 | Glycoprotein (transmembrane) nmb | GPNMB | 0.054288662 | −4.203205255 | 1.31E-10 | 2.47E-06 |
| ENSG00000173369 | Complement component 1, q subcomponent, B chain | C1QB | 0.045270458 | −4.465286294 | 2.03E-06 | 0.004261044 |
| ENSG00000174370 | Chromosome 11 ORF 45 | C11orf45 | 0.025142778 | −5.313712108 | 2.84E-05 | 0.027432543 |
All samples were compared with one another, and all dynamic protein coding genes (∼5,000 genes) were selected at a threshold of adjusted P value < 0.05, fold-change > 2.5, and RPKM > 1. Biologically relevant comparisons have been performed thereafter to study the research question regarding the uric acid effect: the comparison d1_RPMI vs. d1_Uricacid yielded the following set of statistically significant hits.