Table 1.
Elastic Membrane Material Properties Specific to POPC and Prescribed Parameters for All Continuum Calculations
| Parameters | Values | Reference |
|---|---|---|
| Membrane thickness (L0) | 28.5 Å | Kim et al. (16) |
| Surface tension (α) | 3.00 × 10−13 N/Å | Latorraca et al. (32) |
| Bending modulus (KC) | 8.5 × 10−10 NÅ | Kim et al. (16) |
| Gaussian modulus (KG) | ∼−0.9 × Kc | Hu et al. (54) |
| Shell hardening factora (Θ) | ∼4.27 | Partenskii and Jordan (27) |
| Area compression modulus (bulk)a (Ka,B) | 2.13 × 10−11 N/Å | Latorraca et al. (32) |
| Protein dielectric (εp) | 2.0 | Latorraca et al. (32) |
| Membrane dielectric (εhc) | 2.0 | Latorraca et al. (32) |
| Headgroup dielectric (εhg) | 80.0 | Latorraca et al. (32) |
| SASA prefactor for nonpolar energy (a) | 0.028 kcal/(molÅ2) | Sitkoff et al. (91) |
a
We have used nonuniform values of the compression modulus Ka (see Supporting Material). For the remaining parameters necessary for the electrostatic calculations (i.e., electrostatic grid dimensions), we use the same values presented in our previous publication (32).