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Michaelis–Menten and Inhibition Constants of hIDO Associated with Its Reaction with L-Trp in the Presence and Absence of IDE and Those Associated with D-Trp and L-1MTrp (kcat Values Calculated from Vmax/[hIDO])
| L-Trp | +IDE2.5mM | +IDE5.1mM | D-Trp | L-1MTrp | |
|---|---|---|---|---|---|
| kcat (s−1) | 3.1 ± 0.2 | 3.2 ± 0.4 | 3.5 ± 0.6 | 5.9 ± 0.3 | 0.064 ± 0.003 |
| Km (μM) | 15 ± 2 | 16 ± 3 | 15 ± 3 | (2.6 ± 0.2) × 103 | 62 ± 9 |
| Ksi (mM) | 0.17 ± 0.2 | 0.48 ± 0.05 | 1.0 ± 0.1 | – | 5.0 ± 0.8 |
