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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Magn Reson. 2016 Jul 9;270:115–123. doi: 10.1016/j.jmr.2016.07.002

Fig. 5.

Fig. 5

The relative changes in metabolism and membrane transport of hyperpolarized 13C metabolites in UOK262 cells, without and with treatment with DIDS, a high-affinity inhibitor of MCT4. The ratios that reflect LDH activity, or conversion of hyperpolarized 13C pyruvate to 13C lactate, show a significant decrease with DIDS treatment. The membrane transport ratios for hyperpolarized 13C pyruvate do not significantly change with DIDS treatment. The increase in the lactate transport ratios shows that DIDS inhibition of MCT4 leads to a higher intracellular fraction of hyperpolarized 13C lactate. Significant differences with p-value < 0.05 are represented by*.