Fig. 2.

Thermal hyperalgesia data from animals treated with folic acid (FA) following cSCI. a Treatments were given 3 days prior to injury and 17 days post injury, and the TH was performed on day 18 post cSCI. The values are mean ± SE, n = 6/group, paired 2 tail test, * p < 0.0001 (control vs. FA). bi Treatments were given 3 days prior to injury and 14 days post injury, and the TH was performed on days 21, 28, and 35 post cSCI. The values are mean ± SE, n = 8 (control), n = 7 (FA), paired 2 tail test, * p < 0.0001 (control vs. FA). BL, baseline. bii A mixed effect linear regression model for the data in (bi), where the outcome is pain response and the treatment group and time in the model showed a significant difference between FA and water groups (p = 0.002). c Treatments were given 3 days prior to injury and 14 days post cSCI, and the TH was performed on day 42. The values are mean ± SE, n = 6 (water control), n = 5 (FA), n = 2 (sham control). There is no significant difference in latency between the FA and the water groups.