TABLE 1.
DONOR, RECIPIENT, AND TRANSPLANT CHARACTERISTICS
| Characteristic | Donor Arrest (n = 479) | No Donor Cardiac Arrest (Each
Compared against Donor Arrest Group) |
|||
|---|---|---|---|---|---|
| Full Sample (n = 9,076) | P Value | 1:1 Matched (n = 479) | Standardized Difference* | ||
| Donor characteristics | |||||
| Donor age | 30 (21, 44) | 32 (21, 46) | 0.041† | 33 (22, 45) | −0.088 |
| Donor diabetes | 35 (7.3%) | 561 (6.2%) | 0.32 | 31 (6.5%) | 0.032 |
| Donor smoking history | 62 (13.1%) | 1,105 (12.3%) | 0.62 | 55 (11.6%) | 0.046 |
| Donor cocaine use | 67 (14.1%) | 988 (11.1%) | 0.039† | 55 (11.6%) | 0.075 |
| Terminal creatinine, mg/dl | 1.0 (0.8, 1.6) | 1.0 (0.8, 1.3) | <0.001† | 1.0 (0.8, 1.4) | −0.011 |
| Donor BMI, kg/m2 | 25.1 (22.1, 28.7) | 24.7 (22.1, 28.0) | 0.05 | 24.7 (22.1, 27.7) | 0.089 |
| Po2 on 100% inspired oxygen, mm Hg | 405 (214, 488) | 422 (256, 493) | 0.001† | 421 (195, 492) | −0.021 |
| Recipient characteristics | |||||
| Age | 58 (47, 63) | 58 (49, 64) | 0.17 | 58 (47, 64) | 0.005 |
| Female sex | 200 (41.8%) | 3,742 (41.2%) | 0.82 | 200 (41.8%) | 0.000 |
| White ethnicity | 421 (87.9%) | 7,659 (84.4%) | 0.039† | 408 (85.2%) | 0.079 |
| Diagnosis | 0.029† | ||||
| Obstructive | 154 (32.2%) | 3,194 (35.2%) | 143 (29.9%) | 0.050 | |
| Restrictive | 229 (47.8%) | 4,458 (49.1%) | 231 (48.2%) | −0.008 | |
| CF or immunodeficiency | 71 (14.8%) | 1,135 (12.5%) | 75 (15.7%) | −0.025 | |
| Pulmonary vascular | 25 (5.2%) | 289 (3.2%) | 30 (6.3%) | −0.047 | |
| Diabetes | 87 (18.2%) | 1,600 (17.8%) | 0.79 | 91 (19.1%) | −0.023 |
| BMI (kg/m2) at transplant | 24.9 (21.1, 28.4) | 25.1 (21.3, 28.5) | 0.49 | 25.1 (21.2, 28.7) | −0.015 |
| Requiring ventilator at transplant | 34 (7.1%) | 510 (5.6%) | 0.17 | 24 (5.0%) | 0.088 |
| Pulmonary function | |||||
| FEV1, % predicted | 34 (20, 54) | 34 (20, 52) | 0.54 | 36 (21, 56) | −0.046 |
| FVC, % predicted | 46 (36, 59) | 46 (36, 59) | 0.88 | 46 (36, 61) | −0.061 |
| FEV1/FVC | 0.91 (0.47, 1.11) | 0.86 (0.46, 1.10) | 0.30 | 0.87 (0.49, 1.10) | −0.009 |
| Lung allocation score | 39.7 (34.7, 50.0) | 38.9 (34.3, 47.9) | 0.021† | 40.6 (34.7, 49.7) | 0.010 |
| Days on waitlist | 73 (23, 211) | 74 (22, 233) | 0.76 | 65 (21, 211) | 0.001 |
| Transplant characteristics | |||||
| Bilateral transplant | 330 (68.9%) | 5,868 (64.7%) | 0.06 | 329 (68.7%) | 0.004 |
| Sex mismatch | 142 (29.7%) | 2,833 (31.2%) | 0.47 | 164 (34.2%) | −0.097 |
| Donor/recipient race mismatch | 187 (39.0%) | 3,811 (42.0%) | 0.20 | 187 (39.0%) | 0.000 |
| CMV mismatch | 118/439 (26.9%) | 2,141/8,449 (25.3%) | 0.47 | 109/451 (24.2%) | 0.062 |
| Ischemic time, h | 5.2 (4.1, 6.3) | 5.0 (3.9, 6.0) | 0.030† | 5.2 (4.1, 6.3) | 0.018 |
Definition of abbreviations: BMI = body mass index; CF = cystic fibrosis; CMV = cytomegalovirus; Po2 = arterial partial pressure of oxygen.
Shown are the median (interquartile range) for nonparametric continuous variables; n (%) for categorical variables. If data are missing for more than 5% of the study population, the denominator is give for categorical variables and “n” is given for continuous variables. The Wilcoxon signed-rank test was done for continuous variables, and the Pearson chi-squared test was done for categorical variables. Note that matched-pair comparisons of balance using standardized differences are explained in text.
Standardized difference is the difference in mean between the two groups divided by the square root of the pooled variance, with modification to reflect proportions for categorical variables (33).
Statistical significance.