Table 2.
Patient demographic, chest CT features, pathological findings, echocardiographic, and RHC data.
| Case 1 | Case 2 | Case 3 | |
|---|---|---|---|
| Age (years) | 60 | 72 | 63 |
| Sex | Female | Male | Female |
| CT of chest | |||
| Findings and distribution | Diffuse, bilateral, lobular GGOs | Diffuse, bilateral, lobular GGOs and interlobular septal thickening | Diffuse, bilateral, interstitial interlobular septal thickening with peri-lymphatic nodules |
| Fibrosis, pleural, or para-spinal involvement | No | No | No |
| Pathological findings | |||
| EMH | Yes | Yes | Yes |
| Pulmonary arteriopathy | No | Yes | No |
| Other features | – | – | Intra-pulmonary histiocytoid Sweet’s syndrome |
| Echocardiogram | |||
| TR max velocity (m/s) | 4 | – | 3.2 |
| Estimated PAP (mmHg) | 76.2 | 54 | 44.3 |
| TAPSE (cm) | 2.4 | 2.7 | 2.1 |
| RV size | Severely dilated | Normal | Normal |
| RV function | Normal | Normal | Normal |
| Right heart catheterization (baseline hemodynamics) | |||
| RAP (mmHg) | 0 | 6 | Right heart catheterization not performed |
| mPAP (mmHg) | 32 | 28 | |
| PCWP (mmHg) | 12 | 10 | |
| PVR (WU) | 4.4 | 3.63 | |
| Cardiac output (L/min) | 4.5 | 4.9 | |
mPAP, mean pulmonary arterial pressure; PAP, pulmonary arterial pressure; PCWP, pulmonary capillary wedge pressure; PVR, pulmonary vascular resistance; RAP, right atrial pressure; TAPSE, tricuspid annular plane systolic excursion; TR, tricuspid regurgitation; WU, Woods unit.